What is psilocybin?
An article about the active ingredient in Truffles
Psilocybin is a psychedelic compound that occurs in certain mushrooms (often referred to as “magic truffles,” “magic mushrooms” or “shrooms”). Although truffles are officially and legally not included in the mushroom category. The truffles (sclerotia) are therefore still legal in the Netherlands, in contrast to the ‘Magic Mushrooms’, which became illegal and banned in 2007.
Psilocybin mushrooms have a long history of use in Mesoamerica in spiritual and religious rituals and are currently one of the most popular recreational psychedelics in North America and Europe. These mushrooms are increasingly being used in therapeutic settings to treat a wide variety of ailments and disorders, including cluster headaches, obsessive-compulsive disorders, anxiety, depression, and addiction.
Psilocybin mushrooms are categorized as controlled substances, meaning they are psychedelics but legal. Human studies are permitted for their possible use in medical and psychiatric facilities at leading institutions, although these are under strict supervision.
What is Psilocybin?
More than 180 types of “magic” mushrooms produce the psychoactive compound Psilocybin. When you ingest Psilocybin, your gut converts it into another chemical called psilocin, which triggers changes in the brain. It increases activity in the visual cortex, leading to changes in perception. It decreases network activity in the “Default Mode Network,” driving the experience of ego loss; and it increases connectivity among different regions of the brain. Researchers believe it’s the combination of these effects that makes Psilocybin a useful tool for combating depression and addiction, for which research shows support.
One of its main effects is to stimulate a serotonin receptor called “5-HT2A” in the prefrontal cortex. Psychedelics work in this way very directly, because the effect of Serotonin is imitated in the brain.
Stimulating the 5-HT2A receptor leads to two significant results:
- The production of “Brain-Derived Neurotrophic Factor” (BDNF) is like a growth agent for your brain. It stimulates growth, connections and activity. 
- The increased transfer of “glutamate”, which is the neurotransmitter responsible for brain functions such as cognition, learning and memory. 
Glutamate and BDNF work together in ways we still don’t fully understand. What has become clear though, is that having more of these substances leads to many of the benefits that ‘microdosers’ are looking for. 
Psychedelics also ensure that parts of the brain that normally do not communicate with each other, now communicate with each other! These unique connections are formed by dampening the activity of an often overloaded part of our brain called the “Default Mode Network” (DMN). 
The DMN is responsible for a range of different mental activities, including daydreaming, self-reflection, and thinking about the past and future. Some research suggests that depression is linked to an overactive DMN.  It is possible that a very active DMN causes us to think or grind a lot. We analyze ourselves too much. Instead of living in the moment and enjoying the here and now, we spend a lot of time questioning the past and dreaming about the future.
This helps explain why these agents can be used to combat depression and anxiety. Als bijwerking kan er gekomen worden tot inzichten en creatieve perspectieven die anders voor ons onbereikbaar gebleven zouden zijn..
What is microdosing?
Microdosing is consuming amounts of psychedelics such as Psilocybin, whose effects are sub-perceptual. Sub-perceptual means that the effects are subtle or barely noticeable, but can have a noticeable impact on your life. A microdose is usually one-tenth or one-twentieth of a fully effective dose, which ranges from 50 milligrams to 200 milligrams.
In microdosing, a user integrates sub-perceptual doses into their weekly routine. Unlike the recreational use of psychedelics, individuals microdosing consume on a schedule every 2-3 days. They do not experience any deterioration in their normal functioning.
Read more about microdosing by clicking here (link to ‘The third Wave’ – opens in new window).
What are the effects of microdosing psilocybin?
Psilocybin is often referred to as a nootropic, meaning it has numerous functions in the brain that can improve hippocampal health. The hippocampus is the part of the brain that is responsible for learning, but also for converting short-term memory to long-term memory.
Psilocybin can help the hippocampus form new cells, which in turn can lead to what scientists call “the extinction of fear conditioning.” The conditioned fear response is typical in individuals with post-traumatic stress disorder.
According to “The Third Wave,” the effects of a 50mg-250mg microdosage of Psilocybin are:
- Mood Enhancement
- Less stress
- Emotional stability
- Mindfulness, presence and tranquility
- Openness and self-forgiveness
- More empathy and fun
- Flowing conversations
- Relief of persistent conditions such as depression, anxiety, ADD/ADHD, PTSD.
- Increased motivation (e.g. to make positive lifestyle changes)
- Increased focus and productivity
- Elevated Flow States
- Clearer, more connected thinking
- Improved memory
- Enhanced senses
- More appreciation for music, art and creativity.
- Increased creativity
- Easier Meditation
- More pleasure in physical activities and daily tasks
- Relaxation and heightened awareness of the body
- Improved Athletic Endurance
- Increased energy in general (without fear or a subsequent crash)
- Boosting mood, positive or negative
- A slightly calming effect
What Are the Benefits of Microdosing Psilocybin?
Psilocybin can help overcome anxiety reactions, depression, anxiety and the symptoms of mental illness, while also improving cognition and creativity. The Third Wave says that the frequency and intensity of various forms of mental illness are reduced by microdosing Psilocybin psychedelics. These include:
- Anxiety/ Grinding
- ADD/ ADHD
- mood disorders
- Post traumatic stress syndrome
Some psychological states are experienced as positive and can get a boost by using truffles in microdoses. This actually increases these positive qualities.
- Flow state (mental state in which you are completely absorbed in your activities)
- Productivity and focus
- Improved relationships and increased empathy
- Improved athletic coordination
- Leadership Development
Reported benefits of microdosing include:
Improved Mood – Peacefulness, general well-being, calmness, happiness and a reduction in the symptoms of depression. It also includes a greater capacity for emotional connection, a general sense of optimism, and an improved outlook on life.
- Enhanced focus – Includes skills such as the ability to focus or concentrate and improved self-awareness.
- Creativity – Aside from an overall sense of enhanced creativity, this also includes behaviors such as increased openness, heightened curiosity, the ability to change perspectives, and divergent thinking.
- Self effectiveness – This applies to behaviors such as ambition, self-motivation, self-confidence and a sense of freedom of choice. It also relates to improved mental health, including increased introspection, meditation practice, and other aspects of behavior related to self-care.
- More Energy – In this case, “energy” refers to things like mental stimulation, wakefulness, and alertness.
- Social Benefits – In addition to more involvement with others, this category also includes more empathy, a greater sense of belonging and more extroversion.
- Cognitive Benefits – With microdosing, the user experience increased mental clarity, better memory recall and improved problem solving ability.
- Reduced Anxiety – This applies to reducing both general and social anxiety.
- Fysiological Enhancement – Includes improved visual acuity, cardio endurance, migraine and headache reduction, and better sleep quality.
For those struggling with depression, anxiety, PTSD, ADD/ADHD, mood disorders and/or addiction (to name a few), microdosing can bring about many positive changes.
Clinical research has shown that higher doses of psychedelics effectively treat depression, anxiety and addiction. Some examples support the idea that a regular microdosing regimen can have curative benefits for patients with various mental illnesses.
How do I start microdosing?
The average microdose of Psilocybin is 0.50 grams to 1.00 grams.
Take 0.50 grams to 1.00 grams every other day to start microdosing. Some people find their perfect dosage with microdosing for two days, then taking two days off. You may need to experiment to find the dosing schedule that works best for you, as the effects and comfort levels differ per individual.
Once you’ve decided that you’re ready to begin, plan to start your microdosing protocol on a day when you have little to do, where you can be in a place that doesn’t trigger your anxiety. Although the amount of Psilocybin you ingest is sub-perceptual, it can cause or magnify certain emotions or feelings. These emotions and feelings can be positive, but they can also be negative. Think, for example, of a release of stress or the bubbling up of suppressed emotions. So it’s best to be in a comfortable, safe place, where you can process these emotions in peace and quiet. Your environment can have a big impact on your experience. Some prefer to microdose at home, while others may find comfort in nature.
Microdose Bros advises taking on an empty stomach, preferably away from any caffeine. Some ‘microdosers’ find that, depending on the blend, the energy provided by the other supplements are enough to reduce their reliance on coffee or tea. In other cases, they indicate that the dependence on these types of boosters decrease. Eating around the time of your dose won’t completely nullify the effects; however, dosing with fattier foods will increase the length of time it takes for you to feel them.
Individuals who are taking SSRIs should leave a buffer of a minimum of three hours between a microdose and their medication.
In addition to the above comments and recommendations, you decide how you consume the truffles. Some people prefer to microdose in the morning, while others prefer to do it before bed.
After the first few days of the microdosing protocol, your body will quickly build up a tolerance to the truffles and you will have a better idea of when to take them. Some people will find that they may need a higher dose after they build up a tolerance to the mushrooms. It can also happen that after building up a tolerance, people eventually become more sensitive to the effect of the mushrooms/truffles.
Listen to your body and keep a diary to record the changes in the size of your dose, when you take it and how it affects you.
Once you have become familiar with the microdosing protocol, you can safely integrate microdosing into your daily routine and lifestyle.
What Interacts With Psilocybin?
Since Psilocybin is a potent serotonin agonist, it’s best to avoid using it while on medications that alter the serotonin system, such as SSRI antidepressants like Prozac.
Psilocybin should not be mixed with Tramadol, as it can lead to the Serotonin Syndrome.. Be cautious if mixing Psilocybin with amphetamines or recreational drugs, specifically those that have an effect on the workings of your Serotonin levels in the body.
There are no known harmful interactions between cannabis and Psilocybin; however, cannabis may increase the effects of Psilocybin.
A note from James Fadiman on microdosing precautions:
“We specifically do not recommend that people with color blindness, who live with diagnoses of psychotic disorders or along the autism spectrum try microdosing. People with color blindness report lasting visual distortions from microdosing. Literature suggests psychedelics may harm people with psychotic disorders. In our experience, people with diagnoses along the autism spectrum seem to require dosages that far exceed what is traditionally considered microdosing.”
Tip: establish your intention.
Whenever one chooses to undergo a psychedelic experience, having a clear and laser-like intention is incredibly useful to create a positive framework for that journey. It is essential to know what you are striving for whether it is: the goal is to stop a chronic addiction, to recover from a traumatic experience, to discover your purpose in life, or to get in touch with nature.
To know whether your experience with Microdosing is going as hoped, it is important to set a goal for yourself beforehand. This is also known as ‘setting an intention’. An intention helps you remember your goal and use it as an anchor when unexpected things or feelings arise during the trip/journey/experience. After the experience is over, it helps you deconstruct the insights and challenges of your journey within the context of your stated goals, rather than as random events that stand alone.
For some people it is helpful to identify your goals. Your goals may be spiritual: to have direct experience with aspects of your tradition or another tradition, to transcend previous beliefs, or even to transcend the faith itself. Perhaps you are hoping for what is called a ‘oneness experience’, in which there is no separation between your identity and everything else. But your goals can also be social: improved relationships with your partner, children, siblings, parents, colleagues, friends, and spiritual and secular institutions. In addition, goals can be psychological: gaining insight into neurotic patterns, phobias or unresolved anger or sadness. — James Fadiman
How can I buy the Psilocybin Truffles?
On our website you will find everything you need for microdosing in the shop https://microdosebros.nl/store/